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Influence of receptor reserve on β-adrenoceptor-mediated responses in human lung mast cells

1. The effects of the β-adrenoceptor agonists isoprenaline and salbutamol on IgE-mediated histamine release from human lung mast cells (HLMC) were evaluated. Both agonists (10(−10)–10(−5) M) inhibited histamine release in a dose-dependent manner and isoprenaline (pD(2), 8.3±0.1, mean±s.e.mean) was m...

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Autors principals: Drury, Duncan E J, Chong, Lee K, Ghahramani, Parviz, Peachell, Peter T
Format: Artigo
Idioma:Inglês
Publicat: 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565451/
https://ncbi.nlm.nih.gov/pubmed/9690863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701897
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