Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel

1. On the basis of their structure, we compared the ability of 35 xanthine derivatives to activate the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel stably expressed in chinese hamster ovary (CHO) cells using the cell-attached patch clamp and iodide efflux techniques. 2...

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Bibliografiske detaljer
Main Authors: Chappe, V, Mettey, Y, Vierfond, J M, Hanrahan, J W, Gola, M, Verrier, B, Becq, F
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565206/
https://ncbi.nlm.nih.gov/pubmed/9517388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701648
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