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Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABA(C) receptor antagonists

1. γ-Aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) have been shown to activate GABA(C) receptors. In this study, a range of C2, C3, C4 and N-substituted GABA and TACA analogues were examined for activity at GABA(C) receptors. 2. The effects of these compounds were examined by use of...

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Detalhes bibliográficos
Main Authors: Chebib, Mary, Vandenberg, Robert J, Johnston, Graham A R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565102/
https://ncbi.nlm.nih.gov/pubmed/9422798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701533
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