trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (±)-trans-2-aminomethylcyclopropanecarboxylic acid ((±)-TAMP) can differentiate rat ρ3 from human ρ1 and ρ2 recombinant GABA(C) receptors

1. This study investigated the effects of a number of GABA analogues on rat ρ3 GABA(C) receptors expressed in Xenopus oocytes using 2-electrode voltage clamp methods. 2. The potency order of agonists was muscimol (EC(50)=1.9±0.1 μM) (+)-trans-3-aminocyclopentanecarboxylic acids ((+)-TACP; EC(50)=2.7...

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Detalhes bibliográficos
Main Authors: Vien, Jimmy, Duke, Rujee K, Mewett, Kenneth N, Johnston, Graham A R, Shingai, Ryuzo, Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573190/
https://ncbi.nlm.nih.gov/pubmed/11861315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704432
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