Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist

1. The analgesic activity of CP-101,606, an NR2B subunit-selective N-methyl-D-aspartate (NMDA) receptor antagonist, was examined in carrageenan-induced hyperalgesia, capsaicin- and 4β-phorbol-12-myristate-13-acetate (PMA)-induced nociceptive tests in the rat. 2. CP-101,606 30 mg kg(−1), s.c., at 0.5...

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Autors principals: Taniguchi, Kana, Shinjo, Katsuhiro, Mizutani, Mayumi, Shimada, Kaoru, Ishikawa, Toshihisa, Menniti, Frank S, Nagahisa, Atsushi
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565002/
https://ncbi.nlm.nih.gov/pubmed/9384494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701445
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