Effects of a NR2B Selective NMDA Glutamate Antagonist, CP-101,606, on Dyskinesia and Parkinsonism

Glutamate antagonists decrease dyskinesia and augment the antiparkinsonian effects of levodopa in animal models of Parkinson’s disease (PD). In a randomized, double-blind, placebo-controlled clinical trial we investigated the acute effects of placebo and two doses of a NR2B subunit selective NMDA gl...

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Main Authors: Nutt, John G., Gunzler, Steven A, Kirchhoff, Trish, Hogarth, Penelope, Weaver, Jerry L., Krams, Michael, Jamerson, Brenda, Menniti, Frank S., Landen, Jaren W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390310/
https://ncbi.nlm.nih.gov/pubmed/18759356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.22169
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