Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein

1. P-glycoprotein, a 170–180 kDa membrane glycoprotein that mediates multidrug resistance, hydrolyses ATP to efflux a broad spectrum of hydrophobic agents. In this study, we analysed the effects of three MDR reversing agents, verapamil, cyclosporin A and [3′-keto-Bmt]-[Val(*)]-cyclosporin (PSC 833),...

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Bibliografiske detaljer
Main Authors: Watanabe, Toru, Kokubu, Noriko, Charnick, Steven B, Naito, Mikihiko, Tsuruo, Takashi, Cohen, Dalia
Format: Artigo
Sprog:Inglês
Udgivet: 1997
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564934/
https://ncbi.nlm.nih.gov/pubmed/9313931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701377
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