Cyclosporin A Enhances Susceptibility of Multi‐drug Resistant Human Cancer Cells to Anti‐P‐glycoprotein Antibody‐dependent Cytotoxicity of Monocytes, but Not of Lymphocytes

Cyclosporin A (CsA) was previously found to bind to P‐glycoprotein expressed on multidrug‐resistant (MDR) cancer cells. In the present study, the effect of CsA on anti‐P‐glycoprotein monoclonal antibody (mAb)‐dependent cell‐mediated cytotoxicity (ADCC) against human MDR cells was examined. The ADCC...

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Publicado en:Jpn J Cancer Res
Autores principales: Yano, Seiji, Sone, Saburo, Nishioka, Yasuhiko, Naito, Mikihiko, Tsuruo, Takashi, Ogura, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 1994
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919430/
https://ncbi.nlm.nih.gov/pubmed/7511575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02082.x
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