TNF-α downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents

Obesity is associated with chronic low-grade inflammation. Thus, at metabolically relevant sites, including adipose tissue and muscle, there is abnormal production of proinflammatory cytokines such as TNF-α. Here we demonstrate that eNOS expression was reduced, with a concomitant reduction of mitoch...

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Hauptverfasser: Valerio, Alessandra, Cardile, Annalisa, Cozzi, Valeria, Bracale, Renata, Tedesco, Laura, Pisconti, Addolorata, Palomba, Letizia, Cantoni, Orazio, Clementi, Emilio, Moncada, Salvador, Carruba, Michele O., Nisoli, Enzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564431/
https://ncbi.nlm.nih.gov/pubmed/16981010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28570
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