Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

OBJECTIVE—Cannabinoid type 1 (CB1) receptor blockade decreases body weight and adiposity in obese subjects; however, the underlying mechanism is not yet fully understood. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) induces mitochondrial biogenesis and function in adipocytes. This st...

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Detalhes bibliográficos
Main Authors: Tedesco, Laura, Valerio, Alessandra, Cervino, Cristina, Cardile, Annalisa, Pagano, Claudio, Vettor, Roberto, Pasquali, Renato, Carruba, Michele O., Marsicano, Giovanni, Lutz, Beat, Pagotto, Uberto, Nisoli, Enzo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494670/
https://ncbi.nlm.nih.gov/pubmed/18477809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1623
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