Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways

OBJECTIVE: Cannabinoid type 1 (CB1) receptor is involved in whole-body and cellular energy metabolism. We asked whether CB1 receptor stimulation was able to decrease mitochondrial biogenesis in different metabolically active tissues of obese high-fat diet (HFD)-fed mice. RESEARCH DESIGN AND METHODS:...

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Auteurs principaux: Tedesco, Laura, Valerio, Alessandra, Dossena, Marta, Cardile, Annalisa, Ragni, Maurizio, Pagano, Claudio, Pagotto, Uberto, Carruba, Michele O., Vettor, Roberto, Nisoli, Enzo
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2010
Sujets:
Obesity Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963541/
https://ncbi.nlm.nih.gov/pubmed/20739683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1881
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