Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptid...

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Hlavní autoři: Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, Yamanaka, Akihiro, Williams, S. Clay, Richardson, James A., Tsujino, Natsuko, Garry, Mary G., Lerner, Michael R., King, David S., O'Dowd, Brian F., Sakurai, Takeshi, Yanagisawa, Masashi
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC156358/
https://ncbi.nlm.nih.gov/pubmed/12719537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0837789100
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