Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptid...

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Hauptverfasser: Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, Yamanaka, Akihiro, Williams, S. Clay, Richardson, James A., Tsujino, Natsuko, Garry, Mary G., Lerner, Michael R., King, David S., O'Dowd, Brian F., Sakurai, Takeshi, Yanagisawa, Masashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156358/
https://ncbi.nlm.nih.gov/pubmed/12719537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0837789100
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