Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptid...

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Detalhes bibliográficos
Main Authors: Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, Yamanaka, Akihiro, Williams, S. Clay, Richardson, James A., Tsujino, Natsuko, Garry, Mary G., Lerner, Michael R., King, David S., O'Dowd, Brian F., Sakurai, Takeshi, Yanagisawa, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156358/
https://ncbi.nlm.nih.gov/pubmed/12719537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0837789100
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