Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptid...

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Autors principals: Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, Yamanaka, Akihiro, Williams, S. Clay, Richardson, James A., Tsujino, Natsuko, Garry, Mary G., Lerner, Michael R., King, David S., O'Dowd, Brian F., Sakurai, Takeshi, Yanagisawa, Masashi
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC156358/
https://ncbi.nlm.nih.gov/pubmed/12719537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0837789100
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