Effect of Treatment Duration on Pharmacokinetic/Pharmacodynamic Indices Correlating with Therapeutic Efficacy of Ceftazidime in Experimental Klebsiella pneumoniae Lung Infection

The pharmacokinetic/pharmacodynamic (PK/PD) indices that define the therapeutic effect of the beta-lactam ceftazidime in a rat model of Klebsiella pneumoniae lung infection were investigated in relation to treatment duration and treatment endpoint. Treatment was started 24 h after infection with dos...

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Bibliographic Details
Main Authors: Bakker-Woudenberg, Irma A. J. M., ten Kate, Marian T., Goessens, Wil H. F., Mouton, Johan W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563558/
https://ncbi.nlm.nih.gov/pubmed/16940082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00859-05
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