Improved Efficacy of Ciprofloxacin Administered in Polyethylene Glycol-Coated Liposomes for Treatment of Klebsiella pneumoniae Pneumonia in Rats

Animal and clinical data show that high ratios of the area under the concentration-time curve and the peak concentration in blood to the MIC of fluoroquinolones for a given pathogen are associated with a favorable outcome. The present study investigated whether improvement of the therapeutic potenti...

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Bibliographic Details
Main Authors: Bakker-Woudenberg, Irma A. J. M., ten Kate, Marian T., Guo, Luke, Working, Peter, Mouton, Johan W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90493/
https://ncbi.nlm.nih.gov/pubmed/11302815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.5.1487-1492.2001
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