High-Affinity Aptamers to Subtype 3a Hepatitis C Virus Polymerase Display Genotypic Specificity

Research into antiviral agents directed at hepatitis C virus (HCV) proteins is commonly based and tested on a single genotype, namely, genotype 1. This is despite the high level of variability of the RNA virus and the frequency of infection with genotypes other than genotype 1. The systematic evolut...

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Bibliographic Details
Main Authors: Jones, Louisa A., Clancy, Leighton E., Rawlinson, William D., White, Peter A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563542/
https://ncbi.nlm.nih.gov/pubmed/16940097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01603-05
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