DNA synthesis by a polymerase provides the driving force to accelerate DNA unwinding by a helicase

Helicases are molecular motors that use the energy of NTP hydrolysis to translocate along a nucleic acid strand and catalyze reactions such as DNA unwinding. The ring-shaped helicase1 of bacteriophage T7 translocates along single stranded (ss) DNA at a speed of 130 base per second2. However, T7 heli...

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Bibliographic Details
Main Authors: Stano, Natalie M., Jeong, Yong-Joo, Donmez, Ilker, Tummalapalli, Padmaja, Levin, Mikhail K., Patel, Smita S.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563444/
https://ncbi.nlm.nih.gov/pubmed/15902262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03615
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