NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Both inflammatory processes an...

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Hlavní autoři: Wu, Du-Chu, Teismann, Peter, Tieu, Kim, Vila, Miquel, Jackson-Lewis, Vernice, Ischiropoulos, Harry, Przedborski, Serge
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC156340/
https://ncbi.nlm.nih.gov/pubmed/12721370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0937239100
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