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NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Both inflammatory processes and oxi...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Wu, Du-Chu, Teismann, Peter, Tieu, Kim, Vila, Miquel, Jackson-Lewis, Vernice, Ischiropoulos, Harry, Przedborski, Serge
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2003
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156340/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12721370/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0937239100
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