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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the development of various inflammatory diseases. Although there are elevated levels of IL-17 in synovial fluid of patients with rheumatoid arthritis, the pathogenic role of IL-17 in the development of rheumatoid...

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Autors principals: Nakae, Susumu, Saijo, Shinobu, Horai, Reiko, Sudo, Katsuko, Mori, Shigeo, Iwakura, Yoichiro
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC156313/
https://ncbi.nlm.nih.gov/pubmed/12721360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1035999100
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