Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces

Polar residue hot spots have been observed at protein–protein binding sites. Here we show that hot spots occur predominantly at the interfaces of macromolecular complexes, distinguishing binding sites from the remainder of the surface. Consequently, hot spots can be used to define binding epitopes....

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Ma, Buyong, Elkayam, Tal, Wolfson, Haim, Nussinov, Ruth
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2003
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12730379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1030237100
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