Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces
Polar residue hot spots have been observed at protein–protein binding sites. Here we show that hot spots occur predominantly at the interfaces of macromolecular complexes, distinguishing binding sites from the remainder of the surface. Consequently, hot spots can be used to define binding epitopes....
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12730379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1030237100 |
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