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A γ-Secretase-independent Mechanism of Signal Transduction by the Amyloid Precursor Protein
It has been proposed that γ-secretase-mediated release of the amyloid precursor protein (APP) intracellular domain (AICD) results in nuclear translocation and signaling through a complex with the adaptor protein Fe65 and the histone acetyltransferase Tip60. Here, we show that APP and Fe65 activate t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1562327/ https://ncbi.nlm.nih.gov/pubmed/16103124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M502861200 |
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