Identification of Amino Acid Residues in the Capsid Proteins of Adeno-Associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding

The adeno-associated virus type 2 (AAV2) uses heparan sulfate proteoglycan (HSPG) as its primary cellular receptor. In order to identify amino acids within the capsid of AAV2 that contribute to HSPG association, we used biochemical information about heparin and heparin sulfate, AAV serotype protein...

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Bibliographische Detailangaben
Hauptverfasser: Opie, Shaun R., Warrington, Jr., Kenneth H., Agbandje-McKenna, Mavis, Zolotukhin, Sergei, Muzyczka, Nicholas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156206/
https://ncbi.nlm.nih.gov/pubmed/12768018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6995-7006.2003
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