Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity

Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes. Here, we used the NT4 peptide to investigate how the sulfation pattern of HSPG on cells drives binding specificity....

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Hlavní autoři:	Jlenia Brunetti, Giulia Riolo, Lorenzo Depau, Elisabetta Mandarini, Andrea Bernini, Evgenia Karousou, Alberto Passi, Alessandro Pini, Luisa Bracci, Chiara Falciani
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-09-01
Edice:	Frontiers in Oncology
Témata:	heparan sulfate proteoglycans peptide tumor targeting sulfatase oligosaccharide
On-line přístup:	https://www.frontiersin.org/article/10.3389/fonc.2019.00843/full
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