Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21(Cip1) Promoter

DNA methylation in the promoter of certain genes is associated with transcriptional silencing. Methylation affects gene expression directly by interfering with transcription factor binding and/or indirectly by recruiting histone deacetylases through methyl-DNA-binding proteins. In this study, we dem...

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Wei-Guo, Srinivasan, Kanur, Dai, Zunyan, Duan, Wenrui, Druhan, Lawrence J., Ding, Haiming, Yee, Lisa, Villalona-Calero, Miguel A., Plass, Christoph, Otterson, Gregory A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156121/
https://ncbi.nlm.nih.gov/pubmed/12773551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.12.4056-4065.2003
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