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Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21(Cip1) Promoter

DNA methylation in the promoter of certain genes is associated with transcriptional silencing. Methylation affects gene expression directly by interfering with transcription factor binding and/or indirectly by recruiting histone deacetylases through methyl-DNA-binding proteins. In this study, we dem...

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Published in:Mol Cell Biol
Main Authors: Zhu, Wei-Guo, Srinivasan, Kanur, Dai, Zunyan, Duan, Wenrui, Druhan, Lawrence J., Ding, Haiming, Yee, Lisa, Villalona-Calero, Miguel A., Plass, Christoph, Otterson, Gregory A.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2003
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156121/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12773551/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.12.4056-4065.2003
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