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Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

Colorectal cancers (CRCs) are characterized by multiple genetic (mutations) and epigenetic (CpG island methylation) alterations, but it is not known whether these evolve independently through stochastic processes. We have recently described a novel pathway termed CpG island methylator phenotype (CIM...

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Bibliographic Details
Main Authors: Toyota, Minoru, Ohe-Toyota, Mutsumi, Ahuja, Nita, Issa, Jean-Pierre J.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15395/
https://ncbi.nlm.nih.gov/pubmed/10639144
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