Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

The periodic destruction of mitotic cyclins is triggered by the activation of the anaphase-promoting complex/cyclosome (APC/C) in mitosis. Although the ability of the APC/C to recognize destruction box (D-box) substrates oscillates throughout the cell cycle, the mechanism regulating APC/C binding to...

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Détails bibliographiques
Auteurs principaux: Miller, Julie J., Summers, Matthew K., Hansen, David V., Nachury, Maxence V., Lehman, Norman L., Loktev, Alex, Jackson, Peter K.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2006
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560415/
https://ncbi.nlm.nih.gov/pubmed/16921029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1454006
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