Loss of Emi1-Dependent Anaphase-Promoting Complex/Cyclosome Inhibition Deregulates E2F Target Expression and Elicits DNA Damage-Induced Senescence

Expression of the anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 is required for the accumulation of APC/C substrates crucial for DNA synthesis and mitotic entry. We show that in vivo Emi1 expression correlates with the proliferative status of the cellular compartment and that cells lac...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Verschuren, Emmy W., Ban, Kenneth H., Masek, Marilyn A., Lehman, Norman L., Jackson, Peter K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2007
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169152/
https://ncbi.nlm.nih.gov/pubmed/17875940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00908-07
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