Oncogenic Regulators and Substrates of the Anaphase Promoting Complex/Cyclosome Are Frequently Overexpressed in Malignant Tumors

The fidelity of cell division is dependent on the accumulation and ordered destruction of critical protein regulators. By triggering the appropriately timed, ubiquitin-dependent proteolysis of the mitotic regulatory proteins securin, cyclin B, aurora A kinase, and polo-like kinase 1, the anaphase pr...

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Autors principals: Lehman, Norman L., Tibshirani, Rob, Hsu, Jerry Y., Natkunam, Yasodha, Harris, Brent T., West, Robert B., Masek, Marilyn A., Montgomery, Kelli, van de Rijn, Matt, Jackson, Peter K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2007
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854971/
https://ncbi.nlm.nih.gov/pubmed/17456782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060767
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