Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression

Taspase1 was identified as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene expression in vitro. To investigate its functions in vivo, we generated Taspase1(−/−) mice. Taspase1 deficiency results in noncleavage (nc) of MLL and MLL2 and homeotic transformation...

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Hauptverfasser: Takeda, Shugaku, Chen, David Y., Westergard, Todd D., Fisher, Jill K., Rubens, Jeffrey A., Sasagawa, Satoru, Kan, Jason T., Korsmeyer, Stanley J., Cheng, Emily H.-Y., Hsieh, James J.-D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2006
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560414/
https://ncbi.nlm.nih.gov/pubmed/16951254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1449406
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