Generation of Stable Cell Lines Expressing Lamivudine-Resistant Hepatitis B Virus for Antiviral-Compound Screening

Lamivudine [β-l-(−)-2′,3′-dideoxy-3′-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged ther...

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Autori principali: Walters, Kathie-Anne, Tipples, Graham A., Allen, Marchelle I., Condreay, Lynn D., Addison, William R., Tyrrell, Lorne
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC155849/
https://ncbi.nlm.nih.gov/pubmed/12760870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.1936-1942.2003
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