Emergence of Drug-Resistant Populations of Woodchuck Hepatitis Virus in Woodchucks Treated with the Antiviral Nucleoside Lamivudine

Lamivudine [(−)-β-l-2′,3′-dideoxy-3′-thiacytidine] reduces woodchuck hepatitis virus (WHV) titers in the sera of chronically infected woodchucks by inhibiting viral DNA synthesis. However, after 6 to 12 months, WHV titers begin to increase toward pretreatment levels. Three WHV variants with mutation...

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Detalhes bibliográficos
Main Authors: Zhou, Tianlun, Saputelli, Jeffry, Aldrich, Carol E., Deslauriers, Manon, Condreay, Lynn D., Mason, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89396/
https://ncbi.nlm.nih.gov/pubmed/10428918
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