Emergence of Drug-Resistant Populations of Woodchuck Hepatitis Virus in Woodchucks Treated with the Antiviral Nucleoside Lamivudine

Lamivudine [(−)-β-l-2′,3′-dideoxy-3′-thiacytidine] reduces woodchuck hepatitis virus (WHV) titers in the sera of chronically infected woodchucks by inhibiting viral DNA synthesis. However, after 6 to 12 months, WHV titers begin to increase toward pretreatment levels. Three WHV variants with mutation...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Zhou, Tianlun, Saputelli, Jeffry, Aldrich, Carol E., Deslauriers, Manon, Condreay, Lynn D., Mason, William S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428918/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1947
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