Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1

This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACV(r)) infections mediated by the HSV type 1 (HSV-1) dlsptk and PAA(r)5 mutant strains. In vitro, the compound was more...

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Autors principals: Duan, Jianmin, Liuzzi, Michel, Paris, William, Liard, Francine, Browne, Abigail, Dansereau, Nathalie, Simoneau, Bruno, Faucher, Anne-Marie, Cordingley, Michael G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC155846/
https://ncbi.nlm.nih.gov/pubmed/12760851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.1798-1804.2003
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