Herpes Simplex Virus Type 1 Helicase-Primase: DNA Binding and Consequent Protein Oligomerization and Primase Activation

The heterotrimeric helicase-primase complex of herpes simplex virus type I (HSV-1), consisting of UL5, UL8, and UL52, possesses 5′ to 3′ helicase, single-stranded DNA (ssDNA)-dependent ATPase, primase, and DNA binding activities. In this study we confirm that the UL5-UL8-UL52 complex has higher affi...

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Detalhes bibliográficos
Main Authors: Chen, Yan, Bai, Ping, Mackay, Shannon, Korza, George, Carson, John H., Kuchta, Robert D., Weller, Sandra K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019990/
https://ncbi.nlm.nih.gov/pubmed/21068246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01690-10
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