Mutations in the Putative Zinc-Binding Motif of UL52 Demonstrate a Complex Interdependence between the UL5 and UL52 Subunits of the Human Herpes Simplex Virus Type 1 Helicase/Primase Complex

Herpes simplex virus type 1 (HSV-1) encodes a heterotrimeric helicase-primase (UL5/8/52) complex. UL5 contains seven motifs found in helicase superfamily 1, and UL52 contains conserved motifs found in primases. The contributions of each subunit to the biochemical activities of the complex, however,...

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Bibliographic Details
Main Authors: Chen, Yan, Carrington-Lawrence, Stacy D., Bai, Ping, Weller, Sandra K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168741/
https://ncbi.nlm.nih.gov/pubmed/15994803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9088-9096.2005
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