Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA Double-Strand Break-Sensing MRN Complex

The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes...

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Main Authors: Balasubramanian, Nandakumar, Bai, Ping, Buchek, Gregory, Korza, George, Weller, Sandra K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004347/
https://ncbi.nlm.nih.gov/pubmed/20943970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01506-10
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