Antiviral Activity of a Selective Ribonucleotide Reductase Inhibitor against Acyclovir-Resistant Herpes Simplex Virus Type 1 In Vivo

The present study reports the activity of BILD 1633 SE against acyclovir (ACV)-resistant herpes simplex virus (HSV) infections in athymic nude (nu/nu) mice. BILD 1633 SE is a novel peptidomimetic inhibitor of HSV ribonucleotide reductase (RR). In vitro, it is more potent than ACV against several str...

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Autores principales: Duan, Jianmin, Liuzzi, Michel, Paris, William, Lambert, Michelle, Lawetz, Carol, Moss, Neil, Jaramillo, Jorge, Gauthier, Jean, Déziel, Robert, Cordingley, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC105657/
https://ncbi.nlm.nih.gov/pubmed/9660995
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