Antiviral Activity of a Selective Ribonucleotide Reductase Inhibitor against Acyclovir-Resistant Herpes Simplex Virus Type 1 In Vivo

The present study reports the activity of BILD 1633 SE against acyclovir (ACV)-resistant herpes simplex virus (HSV) infections in athymic nude (nu/nu) mice. BILD 1633 SE is a novel peptidomimetic inhibitor of HSV ribonucleotide reductase (RR). In vitro, it is more potent than ACV against several str...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Duan, Jianmin, Liuzzi, Michel, Paris, William, Lambert, Michelle, Lawetz, Carol, Moss, Neil, Jaramillo, Jorge, Gauthier, Jean, Déziel, Robert, Cordingley, Michael G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9660995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1629
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