Potent In Vivo Antiviral Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293

BAY 57-1293 belongs to a new class of antiviral compounds and inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activ...

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Autors principals: Betz, Ulrich A. K., Fischer, Rüdiger, Kleymann, Gerald, Hendrix, Martin, Rübsamen-Waigmann, Helga
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127257/
https://ncbi.nlm.nih.gov/pubmed/12019088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1766-1772.2002
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