Protection against Shiga Toxin 1 Challenge by Immunization of Mice with Purified Mutant Shiga Toxin 1

Shiga toxin 1 (Stx1) of enterohemorrhagic Escherichia coli O157:H7 was cloned, and four mutant Stx1s were constructed by site-directed mutagenesis with PCR. The wild-type and mutant Stx1s with amino acid replacements at positions 167 and 170 of the A subunit were purified by one-step affinity chroma...

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Bibliografiska uppgifter
Huvudupphovsmän: Ishikawa, Satoshi, Kawahara, Kazuyoshi, Kagami, Yutaka, Isshiki, Yasunori, Kaneko, Aki, Matsui, Hidenori, Okada, Nobuhiko, Danbara, Hirofumi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC155758/
https://ncbi.nlm.nih.gov/pubmed/12761104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.6.3235-3239.2003
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