Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Abstract Background Certain peptides that bind Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing Escherichia coli (STEC) infections. However, their mechanisms of action remain unknown. STEC infections lead to serious diseases, such as hemolytic uremic syndrome, in humans. Antibi...

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Hauptverfasser:	Anuja Prabhudesai, Samir Shaikh, Kayasth Zarna Ashwinbhai, Reeshu Gupta
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2024-03-01
Schriftenreihe:	Bulletin of the National Research Centre
Schlagworte:	Shiga toxin-producing E. coli Tetravalent peptide Antibiotics Ribosome binding site Ribosomal P-stalk
Online-Zugang:	https://doi.org/10.1186/s42269-024-01190-6
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