Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Abstract Background Certain peptides that bind Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing Escherichia coli (STEC) infections. However, their mechanisms of action remain unknown. STEC infections lead to serious diseases, such as hemolytic uremic syndrome, in humans. Antibi...

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Principais autores:	Anuja Prabhudesai, Samir Shaikh, Kayasth Zarna Ashwinbhai, Reeshu Gupta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2024-03-01
Colecção:	Bulletin of the National Research Centre
Assuntos:	Shiga toxin-producing E. coli Tetravalent peptide Antibiotics Ribosome binding site Ribosomal P-stalk
Acesso em linha:	https://doi.org/10.1186/s42269-024-01190-6
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