TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality

TNF-related apoptosis–inducing ligand (TRAIL) is a member of the TNF family with potent apoptosis-inducing properties in tumor cells. In particular, TRAIL strongly synergizes with conventional chemotherapeutic drugs to induce tumor cell death. Thus, TRAIL has been proposed as a promising future canc...

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Bibliografiske detaljer
Main Authors: Corazza, Nadia, Jakob, Sabine, Schaer, Corinne, Frese, Steffen, Keogh, Adrian, Stroka, Deborah, Kassahn, Daniela, Torgler, Ralph, Mueller, Christoph, Schneider, Pascal, Brunner, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1555640/
https://ncbi.nlm.nih.gov/pubmed/16955144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27726
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