In vivo treatment with a monoclonal chimeric anti-CD4 antibody results in prolonged depletion of circulating CD4(+) cells in chimpanzees

Chimeric M-T412 (cM-T412), an anti-CD4 antibody, was tolerated in chimpanzees at a dosage of 5 mg/kg per day for up to 7 consecutive days, or 5 mg/kg per dose, twice weekly for 4 weeks. All cM-T412-treated chimpanzees showed a prolonged CD4 cell depression. Weak chimpanzee antibody responses to chim...

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Main Authors: Jonker, M., Slingerland, W., Treacy, G., van Eerd, P., Pak, K. Y., Wilson, E., Tam, S., Bakker, K., Lobuglio, A. F., Rieber, P., Riethmuller, G., Daddona, P. E., Iuliucci, J.
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Experimental Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1554916/
https://ncbi.nlm.nih.gov/pubmed/8103714
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