Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz

Spitz (Spi) is a TGFα homolog that is a cardinal ligand for the Drosophila EGF receptor throughout development. Cleavage of the ubiquitously expressed transmembrane form of Spi (mSpi) precedes EGF receptor activation. We show that the Star and Rhomboid (Rho) proteins are necessary for Spi cleavage i...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Tsruya, Rachel, Schlesinger, Ayelet, Reich, Aderet, Gabay, Limor, Sapir, Amir, Shilo, Ben-Zion
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2002
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155325/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11799065/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.214202
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