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Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling

Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by which EGFR ligands induce dimerization and phosphorylation is not fully understood. Here, we demonstrate that EGFRs...

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Detalhes bibliográficos
Main Authors: Yu, Xiaochun, Sharma, Kailash D., Takahashi, Tsuyoshi, Iwamoto, Ryo, Mekada, Eisuke
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117333/
https://ncbi.nlm.nih.gov/pubmed/12134089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.01-08-0411
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