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Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling

Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by which EGFR ligands induce dimerization and phosphorylation is not fully understood. Here, we demonstrate that EGFRs...

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Udgivet i:Mol Biol Cell
Principais autores: Yu, Xiaochun, Sharma, Kailash D., Takahashi, Tsuyoshi, Iwamoto, Ryo, Mekada, Eisuke
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117333/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12134089/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.01-08-0411
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