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Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

The X-linked disorder oculocerebrorenal syndrome of Lowe is caused by mutation of the OCRL1 protein, an inositol polyphosphate 5-phosphatase. OCRL1 is localised to the Golgi apparatus and early endosomes, and can translocate to lamellipodia upon growth factor stimulation. We show here that OCRL1 int...

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Bibliografski detalji
Glavni autori: Hyvola, Noora, Diao, Aipo, McKenzie, Eddie, Skippen, Alison, Cockcroft, Shamshad, Lowe, Martin
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553191/
https://ncbi.nlm.nih.gov/pubmed/16902405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601274
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